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KMID : 0624620170500080411
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BMB Reports
2017 Volume.50 No. 8 p.411 ~ p.416
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ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
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Wang Xiaokun
Xia Yan
Xu Chentong
Lin Xin
Xue Peng
Zhu Shijie
Bai Yun
Chen Yingyu
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Abstract
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The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohisto-chemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overex-pression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.
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KEYWORD
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Anti-tumor activity, Apoptosis, Cell cycle, EMC6, Gastric cancer
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